Supervisor: Dr Benjamin Beck
Our research laboratory is looking for a candidate interested in unraveling the mechanisms governing esophageal cell plasticity and metaplasia formation. Over the past few years, our laboratory has been at the forefront of investigating the remarkable plasticity exhibited by esophageal cells. We have uncovered that under physiological conditions, esophageal cells possess the remarkable ability to transition from a squamous fate to giving rise to taste buds in the upper esophagus (Science Advances 2023).
Moreover, our research has demonstrated that under pathological conditions associated with chronic gastroesophageal reflux, epithelial cells undergo alterations in their differentiation program. This results in the formation of a distinct pool of cells that resemble the embryonic esophagus (Cell Stem Cell, 2021). We hypothesize that these embryonic-like cells harbor unique properties enabling them to initiate metaplasia, a precursor to adenocarcinoma development (Molecular and Cellular Oncology 2021).
As a PhD candidate joining our dynamic research team, you will have the opportunity to delve into cutting-edge research focusing on three-dimensional culture models of esophageal epithelium. Your primary objectives will include studying the regulation of epithelial cell differentiation programs and elucidating the underlying mechanisms driving metaplasia formation.
Requirements:
-A passion for research in cellular and molecular biology, with a specific interest in epithelial cell plasticity and cancer biology.
-A strong background in cell culture techniques and molecular biology methodologies.
-Proficiency in experimental design, data analysis, and interpretation.
-Excellent communication skills and the ability to work effectively within a collaborative research environment.
-Prior experience with DNA transduction methods, particularly through viral infection, would be advantageous.