Role of P2Y nucleotide receptors in the function and therapeutical potential of cardiac adipose-derived stem cells

Supervisor: Dr. Didier Communi

Our laboratory has performed several studies showing that extracellular nucleotide receptors called P2Y are involved in postnatal heart growth, cardiac angiogenesis and cardioprotection. Protection against infarct has been identified in a model of coronary artery ligation in P2Y4-deficient mice (left artery descending (LAD) ligation model). Cardiac adipose tissue is now well recognized as a therapeutical source of cardiac stem cells allowing the restoring of cardiac function after myocardial infarction. We recently identified the unexpected role of P2Y receptors in the regulation of the cardioprotective properties of cardiac fat such as adiponectin secretion and generation of beige adipocytes. In the proposed project, we will investigate the role of P2Y receptors in the differentiation and function of cardiac stem cells isolated from cardiac adipose tissue. In parallel, we will investigate the therapeutic potential of the injection of nucleotide-treated adipose-derived stem cells in ischemia and ischemia-reperfusion in vivo models.

The study of receptors regulating cardiac fat function, as well as therapeutic potential of adipose-derived stem cells, represents a major interest in the field of cardiovascular disease. It might lead to the pre-clinical validation of P2Y receptors as new targets for the treatment of myocardial ischemia.

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